Structural alteration of myocardial layers in hypertrophic cardiomyopathy

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Myocardial Structural Alteration and Systolic Dysfunction in Preclinical Hypertrophic Cardiomyopathy Mutation Carriers

BACKGROUND To evaluate the presence of myocardial structural alterations and subtle myocardial dysfunction during familial screening in asymptomatic mutation carriers without hypertrophic cardiomyopathy (HCM) phenotype. METHODS AND FINDINGS Sixteen HCM families with pathogenic mutation were studied and 46 patients with phenotype expression (Mut+/Phen+) and 47 patients without phenotype expres...

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Myocardial fibrosis delineation in late gadolinium enhancement images of Hypertrophic Cardiomyopathy patients using deep learning methods

Introduction: Accurate delineation of myocardial fibrosis in Late Gadolinium Enhancement on Cardiac Magnetic Resonance (LGE-CMR) has a crucial role in the assessment and risk stratification of HCM patients. As this is time-consuming and requires expertise, automation can be essential in accelerating this process. This study aims to use Unet-based deep learning methods to automate the mentioned ...

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[Myocardial fibrosis in hypertrophic cardiomyopathy].

Rev Esp Cardiol. 2005;58(5):585-6 585 A 20-year-old man was referred to our myocardial disease unit for family screening. His father presented obstructive hypertrophic cardiomyopathy and had an automatic defibrillator implanted for sustained ventricular tachycardia. His brother had died of sudden death at the age of 12. The patient only reported dyspnea on exertion. In the electrocardiogram (EC...

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Myocardial dysfunction in hypertrophic cardiomyopathy.

Cardiomyopathy To The Editor: We note with interest Nagueh et al’s1 recent observation that the reduction of tissue Doppler (TD) velocities in mitral annulus excursion was highly sensitive and specific for the detection of individuals carrying hypertrophic cardiomyopathy (HCM)–causing mutations in HCM families, even in the prehypertrophic phase. Any clinical tool that can reliably identify subt...

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Mechanisms of Myocardial Ischemia in Hypertrophic Cardiomyopathy

BACKGROUND Angina is common in hypertrophic cardiomyopathy (HCM) and is associated with abnormal myocardial perfusion. Wave intensity analysis improves the understanding of the mechanics of myocardial ischemia. OBJECTIVES Wave intensity analysis was used to describe the mechanisms underlying perfusion abnormalities in patients with HCM. METHODS Simultaneous pressure and flow were measured i...

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ژورنال

عنوان ژورنال: Juntendo Medical Journal

سال: 1998

ISSN: 0022-6769,2188-2134

DOI: 10.14789/pjmj.43.613